While planar xy-tilting stages are readily available on the market, tilting stages for screening objects under a light microscope from various points of view are of very limited availability and currently only at prohibitive costs. With the increased need of digital documentation of microscopic objects, such a system will eventually become more in demand in the future. If motion control is automated and integrated with software capable of extended focal imaging, the speed to generate 3-D interactive movies can be enhanced. Implementation of multiple image alignment functions to match images from one tilting step to the next would make the tedious operations in Adobe Photoshop obsolete. Another step towards interactive virtual microscopy may be achieved by using high-resolution images for movie construction. Virtual slides are already in use in telepathologic or general tele-teaching systems (Glatz-Krieger et al. 2003 and Glatz-Krieger et al. 2006). Zoom image server (ZIS) technology allows smooth scrolling through virtual slide boxes. Advanced ZIS technology may eventually be developed in the future to navigate and zoom through sequences of virtual slide boxes taken at various orientations in an interactive movie.